The Red Devils travel to St Mary’s on a three-game winning streak in all competitions, but they face a tough test against a Southampton side unbeaten in seven.
Fifth-placed Southampton enter this match sitting four points above United, albeit having played a game more than their opponents.
The details of the match
Tuesday’s emphatic 4-1 victory over Basaksehir ensures that, while not officially there yet, the Red Devils are in a very strong position to reach the Champions League last 16.
In the league, meanwhile, they have defeated Everton and West Bromwich Albion in their last two outings to climb into the top half on goal difference.
United were somewhat fortunate to see off a struggling West Brom side last weekend, though, requiring a retaken Bruno Fernandes penalty to get them over the line.
Solskjaer’s men tend to perform better on their travels and they are seeking an eighth consecutive away top-flight win for the first time in their history.
Southampton possible starting lineup:
McCarthy; Walker-Peters, Bednarek, Vestergaard, Bertrand; Armstrong, Ward-Prowse, Romeu, Djenepo; Adams, Walcott
Manchester United possible starting lineup:
De Gea; Wan-Bissaka, Tuanzebe, Maguire, Telles; McTominay, Matic; Greenwood, Fernandes, Rashford; Cavani
Southampton vs Manchester United: prediction
We say: Southampton 1-1 Manchester United. Southampton have won three league matches in a row and are unbeaten in seven overall in a run spanning more than two months.
United are on the verge of setting a new club record of away wins, meanwhile, having won seven in a row on their travels in the top flight.
Factoring in the Red Devils’ midweek exertions, with Southampton given nearly a full week off, we are tipping this one to finish level.